Chronic wounds and Hypoxia
Wound repair is a quiescent mechanism to restore barriers
in multicellular organisms upon injury. In chronic wounds
however, this mechanism prematurely stalls. It is known
that patterns of extracellular signals within the wound
fluid are crucial to healing. Chronic wound healing
conditions are often observed in elderly patients with
poor tissue oxygenation. Impaired re-epithelization is a
hallmark of these wounds.
The observation that many chronic wounds are ischemic has spurred a series of studies evaluating the response of cells exposed to hypoxia. To date, these studies have shown largely beneficial effects from hypoxia such as increased cellular replication and procollagen synthesis. Oxyheal is a new and advanced oxygen therapy.